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Anal Dysplasia

Anal dysplasia is a precancerous condition where abnormal cells are found in the lining of the anus. It is often caused by human papillomavirus (HPV) infection. Regular screening and monitoring of higher risk patient populations are important to prevent the progression to anal cancer.

Histopathology_of_anal_epithelium_with_normal_histology,_low-grade_dysplasia,_high-grade_d

Histopathology of anal epithelium:
A. Normal histology, negative for anal intraepithelial neoplasia lesion (AIN)
B. Low-grade dysplasia, here called low-grade squamous intraepithelial lesion (LSIL)
C. High-grade dysplasia, here called high grade squamous intraepithelial lesion (HSIL)
D. Squamous cell carcinoma, infiltrating the stroma (middle and left in image), and HSIL (right in image)

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Image Credit: Article authors:Cristina Rovelli, Andrea Poli, Laura Galli, Massimo Cernuschi, Sara Racca, Giuseppe Tambussi, Serena Rolla, Luca Albarello, Riccardo Rosati, Adriano Lazzarin, Antonella Castagna, Silvia Nozza, CC BY 4.0 , via Wikimedia Commons

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